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LU

Emma Hammarlund

Research team manager

LU

Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways

Author

  • Robert A. Gatenby
  • Kimberly A. Luddy
  • Jamie K. Teer
  • Anders Berglund
  • Audrey R. Freischel
  • Ryan M. Carr
  • Amanda E. Lam
  • Kenneth J. Pienta
  • Sarah R. Amend
  • Robert H. Austin
  • Emma U. Hammarlund
  • John L. Cleveland
  • Kenneth Y. Tsai
  • Joel S. Brown
Show all

Summary, in English

Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are molecularly heterogeneous, we hypothesized convergent adaptive strategies to common host selection forces can be inferred from patterns of epigenetic and genetic evolutionary selection in similar tumors. We systematically investigated gene mutations and expression changes in lung adenocarcinomas with no common driver genes (n = 313). Although 13,461 genes were mutated in at least one sample, only 376 non-synonymous mutations evidenced positive evolutionary selection with conservation of 224 genes, while 1736 and 2430 genes exhibited ≥ two-fold increased and ≥ 50% decreased expression, respectively. Mutations under positive selection are more frequent in genes with significantly altered expression suggesting they often “hardwire” pre-existing epigenetically driven adaptations. Conserved genes averaged 16-fold higher expression in normal lung tissue compared to those with selected mutations demonstrating pathways necessary for both normal cell function and optimal cancer cell fitness. The convergent LUAD phenotype exhibits loss of differentiated functions and cell–cell interactions governing tissue organization. Conservation with increased expression is found in genes associated with cell cycle, DNA repair, p53 pathway, epigenetic modifiers, and glucose metabolism. No canonical driver gene pathways exhibit strong positive selection, but extensive down-regulation of membrane ion channels suggests decreased transmembrane potential may generate persistent proliferative signals. NCD LUADs perform niche construction generating a stiff, immunosuppressive microenvironment through selection of specific collagens and proteases. NCD LUADs evolve to a convergent phenotype through a network of interconnected genetic, epigenetic, and ecological pathways.

Department/s

  • StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
  • EpiHealth: Epidemiology for Health
  • Molecular Evolution
  • LUCC: Lund University Cancer Centre

Publishing year

2024-06

Language

English

Publication/Series

Medical Oncology

Volume

41

Issue

6

Document type

Journal article

Publisher

Humana Press

Topic

  • Genetics

Keywords

  • Cancer ecology
  • Cancer evolution
  • Co-adapted syndromes
  • Driver phenotype
  • Evolutionary triage
  • Lung adenocarcinoma

Status

Published

Research group

  • Molecular Evolution

ISBN/ISSN/Other

  • ISSN: 1357-0560